Years of rigorous research went into developing a product to directly support aspects of mind and body that impact sleep quality. When researching and sourcing ingredients, our PhD-led formulations team followed a strict set of core principles to ensure the supplements were:

  • Effective: with clinically proven ingredient dosages + higher bioactives
  • Minimal: without gluten, dairy, sugar, allergens, or artificial colors/binders
  • High-quality: with unique, natural ingredients backed by clinical evidence in human trials
  • Standardized: to guarantee consistent potency, purity, + efficacy

Below, we dive into the science behind our sourcing, and the principles that continue to guide us.

Our supplements are formulated with natural botanicals that have been clinically studied (in humans) and proven to support sleep. But...and this is important...we also make sure to include the ingredients at the dosage levels that have been proven effective in order to maximize the benefits of each supplement.

In a human clinical study, 50 mg/day significantly improved subjects’ ability to initiate and maintain sleep throughout the night. (1)

In a human clinical study, 250 mg/day significantly improved subjects’ cognitive performance. (2)

In a human clinical study, 250 mg/day was shown to reduce the number of upper respiratory tract infection (URTI) symptoms. (3)

In a human clinical study, 125 mg/day was shown to reduce occasional sleeplessness 2x more than placebo. Additionally, subjects reported ~62% lower stress + anxiety levels than those taking the placebo. (4)

READ MORE: The Proper Guide To Ashwagandha For Stress + Anxiety

Our supplements were specially designed with ingredients that respond differently depending on what stage of sleep you’re in, whether it’s REM (active sleep) or non-REM (quiet sleep), for support throughout the entire night.

What happens: Brain activity begins to slow down
Why important: It’s your “portal” into sleep
Ingredients that help: GABA, valerian, L-theanine, standard melatonin

What happens: Core body temperature drops + muscles fully relax
Why important: Supports the consolidation of memories
Ingredients that help: Venetron®, Sensoril® Ashwagandha, extended-release melatonin

What happens: Brain releases low-frequency, high-amplitude delta waves that cause heart rate + respiration to slow
Why important: Supports the functioning + restoration of the immune system
Ingredients that help: Venetron®, Sensoril® Ashwagandha, extended-release melatonin

What happens: Brain waves are active although muscles remain relaxed—the prime time for dreams!
Why important: Benefits cognitive functions (memory consolidation, creativity, learning)
Ingredients that help: Sensoril® Ashwagandha, extended-release melatonin

Because of certain mechanisms of action, the combination select ingredients leads to a more significant benefit in increasing overall sleep time and decreasing awake time. We took the science behind these synergistic relationships into account when deciding which ingredients to include in each formulation. The combination of GABA and L-theanine in Sleep + Calm is the perfect example.

Gamma-Aminobutyric acid (aka GABA) is an amino acid produced naturally in the brain. It acts as an inhibitory neurotransmitter that blocks certain brain signals and decreases activity in your nervous system. Glutamate works in reverse as an excitatory neurotransmitter that stimulates nerve cells. Low GABA equals high glutamate, and vice versa.

Studies have shown (5) that the combination of both L-theanine and GABA in supplement form is more beneficial for the quantity and quality of sleep than the individual ingredients alone. Specifically, the mixture can lead to decreases in sleep latency and increases in sleep duration.

The results “demonstrate that the combined use of GABA and L-theanine increase sleep activity to more than a single administration of either amino acid or these synergistic sleep-promoting effects are likely mediated via changes in GABA and/or glutamate receptor expression in the brain,” conclude researchers. (6)

Our products were formulated to fit into a nightly routine for better sleep health—a lifestyle change and commitment versus one-off “band-aid” use. That’s why we strategically chose ingredients whose benefits build over time.


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