Sleep + Immunity

Sleep + Immunity builds on our Core formulation to help promote sleep health in addition to maintaining a healthy immune system function.

  • Support a healthy immune response
  • Contains clinically-studied Wellmune®
  • Natural, non-GMO, sugar-free, no artificial colors or binders

When should I take Sleep + Immunity?

Take 2 capsules with water 30-40 minutes before bed.

How long does Sleep + Immunity take to begin working?

Although everyone metabolizes ingredients at different rates, you should start feeling the benefits of supported sleep the first night that you take it. Continual sleep improvements will follow over the next 3-5 days, with the full benefits of this supplement's vitamins, minerals, and clinically-studied, immunity-boosting ingredient, Wellmune®, realized after continued daily usage for at least 10 days.

Are there any artificial colors or binders in Sleep + Immunity?

Nope. Proper’s natural, non-GMO supplements are made with botanical extracts, which is why you may notice that they carry a subtle earthy, barn-like aroma. While we could have masked it, we didn’t want to add artificial colors and/or binders that would have compromised the product's purity.

Is Sleep + Immunity safe to take long-term?

Yes. Proper’s supplements are carefully formulated by Dr. Alice Hirschel, our resident PhD in Nutritional Biochemistry, and reviewed by a world-class panel of medical experts in sleep, integrative, and naturopathic medicine. They are drug-free, non-habit-forming, and safe to take for both short and long-term sleep health.

Sleep + Immunity is for anyone who struggles with poor sleep health (falling asleep, staying asleep, and/or feeling rested upon waking) and is also looking to boost the immune system. The primary difference between this supplement and Core Sleep is the addition of Wellmune®—the clinically-studied ingredient with effective immune-boosting properties that powers this supplement—along with zinc, vitamin C, vitamin B6, and vitamin D—all of which work to help build a healthy immune response over time.

Powered by Wellmune® to help you strengthen your immune system.

Wellmune clinical results graph

Results:

In a human clinical study, 250 mg/day of Wellmune® was shown to reduce the number of URTI symptoms supporting a healthy immune response and help strengthen the immune system.

How were the results measured:

A daily health log containing pre-selected questions specific to upper respiratory tract infection (URTI) symptoms—with higher scores indicating more URTI symptoms. Subjects taking Wellmune® reported a 71% decrease in reported URTIs compared to those taking the placebo.


Serving Size: 2 Capsules
Servings Per Container: 30

Amount per serving%DV
Vitamin C (as Ascorbic Acid)50mg56%
Zinc (as Zinc Glycinate Chelate)50mg zinc glycinate chelate (providing 11mg elemental zinc) 100%
Vitamin D (as Cholecalciferol)25 mcg (1000 IU)125%
Vitamin B6 (as Pyridoxine Hydrochloride)1.7 mg100%
Valerian Root Extract (Valeriana officinalis) (std. to 0.8% Valerenic acid)300mg**
Wellmune® (Baker’s Yeast Beta 1,3/1,6 Glucan)250mg**
SENSORIL® Ashwagandha Root and Leaf Extract (Withania somnifera) (std. to 10% Withanolides)125mg**
GABA (Gamma-Aminobutyric acid)100mg**
VENETRON® Rafuma Leaf Extract (Apocynum venetum) (std. to 4% of Hyperoside & isoquercitrin)50mg**
**Daily Value (DV) not established

Other Ingredients: Vegetable Cellulose Capsule, Organic Rice Hulls Contains <2% Of: Ascorbyl Palmitate, Calcium Silicate

SENSORIL® is a registered trademark of Natreon, Inc.
Venetron® is a registered trademark of Tokiwa Phytochemical Co., Ltd.
Wellmune® is a registered trademark of Kerry Group.


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Sleep + Immunity

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Sleep + Immunity builds on our Core formulation to help promote sleep health in addition to maintaining a healthy immune system function.

  • Support a healthy immune response
  • Contains clinically-studied Wellmune®
  • Natural, non-GMO, sugar-free, no artificial colors or binders

When should I take Sleep + Immunity?

Take 2 capsules with water 30-40 minutes before bed.

How long does Sleep + Immunity take to begin working?

Although everyone metabolizes ingredients at different rates, you should start feeling the benefits of supported sleep the first night that you take it. Continual sleep improvements will follow over the next 3-5 days, with the full benefits of this supplement's vitamins, minerals, and clinically-studied, immunity-boosting ingredient, Wellmune®, realized after continued daily usage for at least 10 days.

Are there any artificial colors or binders in Sleep + Immunity?

Nope. Proper’s natural, non-GMO supplements are made with botanical extracts, which is why you may notice that they carry a subtle earthy, barn-like aroma. While we could have masked it, we didn’t want to add artificial colors and/or binders that would have compromised the product's purity.

Is Sleep + Immunity safe to take long-term?

Yes. Proper’s supplements are carefully formulated by Dr. Alice Hirschel, our resident PhD in Nutritional Biochemistry, and reviewed by a world-class panel of medical experts in sleep, integrative, and naturopathic medicine. They are drug-free, non-habit-forming, and safe to take for both short and long-term sleep health.

Sleep + Immunity is for anyone who struggles with poor sleep health (falling asleep, staying asleep, and/or feeling rested upon waking) and is also looking to boost the immune system. The primary difference between this supplement and Core Sleep is the addition of Wellmune®—the clinically-studied ingredient with effective immune-boosting properties that powers this supplement—along with zinc, vitamin C, vitamin B6, and vitamin D—all of which work to help build a healthy immune response over time.

Powered by Wellmune® to help you strengthen your immune system.

Wellmune clinical results graph

Results:

In a human clinical study, 250 mg/day of Wellmune® was shown to reduce the number of URTI symptoms supporting a healthy immune response and help strengthen the immune system.

How were the results measured:

A daily health log containing pre-selected questions specific to upper respiratory tract infection (URTI) symptoms—with higher scores indicating more URTI symptoms. Subjects taking Wellmune® reported a 71% decrease in reported URTIs compared to those taking the placebo.


Serving Size: 2 Capsules
Servings Per Container: 30

Amount per serving%DV
Vitamin C (as Ascorbic Acid)50mg56%
Zinc (as Zinc Glycinate Chelate)50mg zinc glycinate chelate (providing 11mg elemental zinc) 100%
Vitamin D (as Cholecalciferol)25 mcg (1000 IU)125%
Vitamin B6 (as Pyridoxine Hydrochloride)1.7 mg100%
Valerian Root Extract (Valeriana officinalis) (std. to 0.8% Valerenic acid)300mg**
Wellmune® (Baker’s Yeast Beta 1,3/1,6 Glucan)250mg**
SENSORIL® Ashwagandha Root and Leaf Extract (Withania somnifera) (std. to 10% Withanolides)125mg**
GABA (Gamma-Aminobutyric acid)100mg**
VENETRON® Rafuma Leaf Extract (Apocynum venetum) (std. to 4% of Hyperoside & isoquercitrin)50mg**
**Daily Value (DV) not established

Other Ingredients: Vegetable Cellulose Capsule, Organic Rice Hulls Contains <2% Of: Ascorbyl Palmitate, Calcium Silicate

SENSORIL® is a registered trademark of Natreon, Inc.
Venetron® is a registered trademark of Tokiwa Phytochemical Co., Ltd.
Wellmune® is a registered trademark of Kerry Group.


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Ingredients

Wellmune beta glucan image

Ingredient story:

Wellmune® is a natural beta 1,3/1,6 glucan which is highly purified from the cell wall of a proprietary baker’s yeast. Taken daily, Wellmune® has been shown in over 12 human clinical trials to support a healthy immune response. It is taken up in the body by the Peyer’s Patches in the intestine. Clinical benefits have been shown to take effect within two weeks. Research shows that Wellmune® also helps reduce the incidence of upper respiratory tract infection symptoms and improve an overall sense of well-being in people of all ages experiencing physical or lifestyle stress.

Highlights:

  • Supports a healthy immune system + response
  • Supports the body's immune cell function
  • Helps strengthen the immune system

Dosing:

Sleep + Immunity contains 250 mg of Wellmune®, a dosage at which clinical benefits have been shown.

Citations:

  • Carpenter, K. C., W. L. Breslin, T. Davidson, A. Adams, and B. K. Mcfarlin. “Baker's Yeast β-Glucan Supplementation Increases Monocytes and Cytokines Post-Exercise: Implications for Infection Risk?” British Journal of Nutrition 109, no. 3 (2012): 478–86.
  • Mcfarlin, Brian K., Adam S. Venable, Katie C. Carpenter, Andrea L. Henning, and Stephan Ogenstad. “Oral Supplementation with Baker's Yeast Beta Glucan Is Associated with Altered Monocytes, T Cells and Cytokines Following a Bout of Strenuous Exercise.” Frontiers in Physiology 8 (2017).
  • Talbott, Shawn M., and Julie A. Talbott. “Baker's Yeast Beta-Glucan Supplement Reduces Upper Respiratory Symptoms and Improves Mood State in Stressed Women.” Journal of the American College of Nutrition 31, no. 4 (2012): 295–300.
  • Talbott, S. and Talbott, J., 2009. Effect of BETA 1, 3/1, 6 GLUCAN on Upper Respiratory Tract Infection Symptoms and Mood State in Marathon Athletes. Journal of Sports Science and Medicine, 8, pp.509-515.
Vitamin C image

Ingredient story:

Vitamin C (ascorbic acid) is an essential water-soluble vitamin that must be obtained via diet (good sources include fresh vegetables and fruits, especially citrus fruits) or supplements. This potent antioxidant helps support the body’s natural resistance, in addition to healthy teeth, bones, and skin.

Highlights:

  • Supports a healthy immune system + response
  • Protects against free radical damage
  • Helps support the body’s natural resistance
  • Supports healthy teeth + bones
  • Involved in collagen synthesis
  • Necessary for iron absorption
  • Supports hormone metabolism
  • Supports skin health

Dosing:

Sleep + Immunity contains 50mg of vitamin C as ascorbic acid, which represents 56% of the Recommended Dietary Allowance (RDA).

Citations:

  • Carr, Anitra C, and Silvia Maggini. 2017. “Vitamin C and Immune Function.” Nutrients 9 (11): 1211.
Vitamin D image

Ingredient story:

Vitamin D (1,25-dihydroxyvitamin D3) is an essential fat-soluble vitamin that must be obtained via sun exposure or diet. It functions as an immune system modulator and steroid hormone that regulates the expression of a variety of target genes. To help protect against infections caused by pathogens, Vitamin D regulates key antimicrobial proteins, stimulates immune cell proliferation, and increases cytokine (proteins that impact cell signaling) production.

Highlights:

  • Supports a healthy immune system + response
  • Supports healthy teeth + bones
  • Facilitates calcium + phosphorus absorption

Dosing:

Sleep + Immunity contains 25 mcg (1000 IU) of vitamin d as cholecalciferol, which represents 125% of the Recommended Dietary Allowance (RDA).

Citations:

  • Aranow, Cynthia. 2011. “Vitamin D and the Immune System.” Journal of Investigative Medicine : The Official Publication of the American Federation for Clinical Research 59 (6): 881–86.
Vitamin B6

Ingredient story:

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that must be obtained via diet (good sources include animal protein—e.g., pork, poultry, fish, and eggs—tofu, and avocados) or supplements. Vitamin B6 supports many biochemical reactions in the immune system and is involved in the regulation of immune responses.

Highlights:

  • Supports healthy immune function
  • Essential for macronutrient metabolism
  • Supports nervous system function

Dosing:

Sleep + Immunity contains 1.7 mg of vitamin B6 as pyridoxine hydrochloride, which represents 100% of the Recommended Dietary Allowance (RDA).

Citations:

  • Yoshii, Ken, Koji Hosomi, Kento Sawane, and Jun Kunisawa. 2019. “Metabolism of Dietary and Microbial Vitamin B Family in the Regulation of Host Immunity.” Frontiers in Nutrition 6 (April).
Zinc ingredient image

Ingredient story:

Zinc is an essential mineral that must be obtained via diet (good sources include oysters, red meat, poultry, beans, and nuts) or supplements. The human body requires zinc for the development and functioning of immune cells.

Highlights:

  • Supports healthy immune function + response
  • Essential in majority of metabolic processes
  • Necessary for carbohydrate metabolism
  • Essential for bone matrix formulation
  • Involved in collagen synthesis

Dosing:

Sleep + Immunity contains 11 mg of elemental zinc from zinc glycinate chelate, which represents 100% of the Recommended Dietary Allowance (RDA).

Citations:

  • Prasad, Ananda S. 2008. “Zinc in Human Health: Effect of Zinc on Immune Cells.” Molecular Medicine 14 (5–6): 353–57.
  • Hojyo, Shintaro, and Toshiyuki Fukada. 2016. “Roles of Zinc Signaling in the Immune System.” Journal of Immunology Research 2016: 1–21.

Ingredient story:

Valeriana officinalis, commonly known as valerian, is an herb native to Europe and Asia whose roots have been used since ancient Greek and Roman times as a sleep promoter. It plays a role prior to and during N1, when the body needs to feel calm, relaxed, and drowsy in order to move to N2. By working synergistically with a natural amino acid known as GABA, valerian root extract  increases the likelihood that GABA will bind to its receptor, thus ensuring a more relaxed, calm state. Valerian has also been shown to decrease the removal of GABA, allowing it to perform its calming function longer.

Highlights:

  • Binds to the GABA-A receptor, beta subunitResult: Causes an increase in chloride into the neuron
  • Increases the likelihood GABA will bind to its receptorResult: Ensures a less stimulated response
  • Decreases the metabolism or removal of GABA in the neuronResult: Allows GABA to perform its function longer

Dosing:

Core Sleep contains 300 mg of valerian standardized to a clinically beneficial dosage of 0.8%.

Citations:

  • Leathwood, Peter D., Françoise Chauffard, Eva Heck, and Raphael Munoz-Box. “Aqueous Extract of Valerian Root (Valeriana Officinalis L.) Improves Sleep Quality in Man.” Pharmacology Biochemistry and Behavior 17, no. 1 (1982): 65–71.
  • Oxman, Andrew D., Signe Flottorp, Kari Håvelsrud, Atle Fretheim, Jan Odgaard-Jensen, Astrid Austvoll-Dahlgren, Cheryl Carling, Ståle Pallesen, and Bjørn Bjorvatn. “A Televised, Web-Based Randomised Trial of an Herbal Remedy (Valerian) for Insomnia.” PLOS ONE. Public Library of Science. Accessed June 16, 2020.
  • Santos, Maria, Fernanda Ferreira, António Cunha, Arsélio Carvalho, and Tice Macedo. “An Aqueous Extract of Valerian Influences the Transport of GABA in Synaptosomes.” Planta Medica 60, no. 03 (1994): 278–79.
  • Morazzoni P, Bombardelli E. “Valeriana officinalis: traditional use and recent evaluation of activity.” Fitoterapia 66: 99-112 (1995)

Ingredient story:

Ashwagandha is an adaptogen derived from the leaves and roots of the Withania somnifera plant. It has been used in traditional Ayurveda for thousands of years in parts of the Indian sub-continent to promote longevity, enhance vitality, support a healthy immune response, enhance focus, and help reduce everyday stress and fatigue. The Sensoril® Ashwagandha in our formulation is derived from a unique extract that has been studied in 14 human clinical trials. It is standardized to 3 bioactives:

  1. WITHANOLIDE GLYCOSIDES: Glycosylated Steroidal Lactone (Withanolide), which is believed to be responsible for reducing everyday stress
  2. OLIGOSACCHARIDE: carrier of Withanolide Glycosides, thus enhancing its bioactivity
  3. WITHAFERIN A: Steroidal Lactone (Withanolide), which is antioxidant-rich

When standardized to >10% withanolide glycosides, Sensoril® Ashwagandha has been shown to reduce everyday stress, promote a healthy immune system, and relieve occasional sleeplessness.

Highlights:

  • Decreases cortisol, a key marker of stress
  • Reduces malondialdehyde (MDA), a key marker of oxidative stress
  • Relieves occasional sleeplessness

Dosing:

Core Sleep contains a clinically beneficial dosage + standardization level of 125 mg of Sensoril® Ashwagandha.

Citations:

  • Auddy B, Hazra J, Mitra A, Abedon B, Ghosal S. “A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans: A double-blind, randomized, placebo-controlled study.” JANA. 2008;11(1): 50-56.

Ingredient story:

Gamma-Aminobutyric acid (GABA) is an amino acid produced naturally in the brain that acts as the chief inhibitory neurotransmitter in the central nervous system. When GABA binds to its receptor (GABA-A), it renders the neuron less responsive to stimulation. In essence, it suppresses or inhibits the central nervous system to reduce excitability and, when bound, produces an immediate calming effect that may support a reduction in stress, anxiety, and sleeplessness.

Highlights:

  • Reduces excitability
  • Promotes relaxation + calmness

Dosing:

Core Sleep contains a clinically beneficial dosage of 100 mg of GABA.

Citations:

  • Abdou, Adham M., S. Higashiguchi, K. Horie, Mujo Kim, H. Hatta, and H. Yokogoshi. “Relaxation and Immunity Enhancement Effects of γ-Aminobutyric Acid (GABA) Administration in Humans.” BioFactors 26, no. 3 (2006): 201–8.
  • Gottesmann, Claude. “GABA Mechanisms and Sleep.” Neuroscience. Pergamon, April 22, 2002.

Ingredient story:

Venetron® is a patented, purified, powdered extract from the leaves of Apocynum venetum L. (or “Rafuma” in Japanese), a wild perennial plant native to Central Asia and warm regions in Europe. It has been used for centuries to promote sleep health. By binding to the GABA-A receptor, it reduces excitability and produces a calming effect.

When standardized to more than 4% hyperoside and isoquercitrin, Venetron® has been shown to impact multiple stages of sleep beyond those that GABA alone targets—including N1 and N2, where it has been clinically shown to help sleep initiation, and N3, where it has been shown to increase delta waves and enhance non-REM sleep time.

Highlights:

  • Improves initiation + maintenance of sleep
  • Helps you fall asleep faster + stay asleep
  • Reduces feelings of nervousness, restlessness, + irritation

Dosing:

Core Sleep contains a clinically beneficial dosage + standardization level of 50 mg of Venetron®.

Citations:

  • Yamatsu, Atsushi, Yusuke Yamashita, Isafumi Maru, Jinwei Yang, Jin Tatsuzaki, and Mujo Kim. “The Improvement of Sleep by Oral Intake of GABA and Apocynum Venetum Leaf Extract.” Journal of Nutritional Science and Vitaminology 61, no. 2 (2015): 182–87.
  • Nakata, A. et al. “Effect of an Apocynum venetum leaf extract (venetron™) on sleep quality and psychological stress improvement.” Japan Pharmacology Therapeutics (JPT), no. 46 (2018): 117-125.

Pair Sleep + Immunity with personalized coaching to optimize your long-term sleep quality

Consult with a board-certified coach, who will help you address underlying causes of your sleep problems and build healthy, sustainable sleep habits.

Proper coaching image

Get a personalized sleep action plan

  • Complete a detailed diagnostic questionnaire to understand your sleep concerns and goals
  • Schedule a 1:1 video / phone consultation with a certified sleep coach
  • Receive a personalized sleep improvement plan with actionable steps to improve your sleep

I've never felt so ready to wake up early and own the day as I have after taking Proper - I am sleeping uninterrupted from the time I get in bed until it's time to wake up. I am 0% groggy, 100% recharged.

Gaeb C., New Jersey

Proper

Safe

Safe, drug-free, and non habit-forming. No antihistamines and no alcohol.

Effective

PhD-designed formulas contain ingredients at dosage levels clinically proven to improve your sleep.

Minimal

Natural, vegan, gluten/dairy/sugar-free, non-GMO. No artificial colors or binders.

More than Melatonin

It’s great to have options. Melatonin is perfect for some, not for others.

Clean

We third-party test every formula for purity, and verify the absence of heavy metals, microbes, pesticides.

Standard

All of our botanical ingredients are standardized extracts to guarantee consistent purity, potency, and efficacy.

Quality

High quality, natural, and unique ingredients backed by clinical evidence in human trials.

U.S. Manufactured

Produced in a FDA approved facility that is Good Manufacturing Practices and Guidelines (CGMP) compliant.

Thoughtfully delivered natural sleep aids

Proper supplement capsules
  • Small capsules, big impact.
  • Capsules are designed for efficacy, potency, and minimalism
  • Smaller capsules lead to greater adherence
  • No refrigeration needed
  • Refillable glass jar
  • Recyclable cardboard packaging
  • Our pouches are recyclable and the padded envelope used to ship these pouches is made of 100% recycled paper

Warning

For adults 18 and over only. If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Keep out of reach of children. Do not use it if the seal under the cap is broken or missing. Store at room temperature. Do not consume alcohol, drive or operate machinery after taking this product.