Sleep + Immunity

Sleep + Immunity builds on our Core formulation to help promote sleep health and maintain a healthy immune system function. Unique botanicals work synergistically to help you gently fall and stay asleep so you wake up feeling refreshed and restored, not groggy. Think of it as a "sleep vitamin" to add to your ongoing wellness routine.

Natural + non-habit-forming
Take for at least 5 consecutive nights to start feeling the effects, with full benefits realized after 4 weeks
Contains clinically-studied Wellmune®
Vegan, gluten/allergen/nut/soy/sugar-free, non-GMO, no artificial colors or flavors

When should I take Sleep + Immunity?

Take 2 capsules with water 30-40 minutes before bed.

How long does Sleep + Immunity take to begin working?

Take Sleep + Immunity for at least 5 consecutive nights to begin feeling the benefits of supported, high-quality sleep. Many will feel the effects the first night or within several days; however, for maximum benefits, 4 weeks of regular usage is recommended. Results will vary based on your biochemistry and metabolism.

Long-term sleep health can sometimes require more than supplementation. To ensure you're doing all you can to maximize the quantity and quality of your sleep, partner with one of our expert sleep coaches.

How will I feel?

Proper will gently help you relax, fall asleep, and stay asleep. Simply put, it will feel like a good, natural night of sleep.

Do not expect to feel "knocked out," drugged, or groggy. You will awake to normal noises.

79% of Proper customers had less frequent issues staying asleep and 78% were more satisfied with waking up refreshed.*

*Based on formula evaluation data from Proper customers who purchased the Discovery Pack between April 1, 2021 and July 4, 2021 and filled out a Baseline Sleep Assessment and at least one Formula Evaluation (n=75).

What's that smell?

Our formulations contain natural botanicals such as valerian root extract and Sensoril® Ashwagandha, which carry an earthy, barn-like aroma. Instead of using artificial colors or scents to mask it, we opted to include one small, all-natural, FDA-compliant peppermint sachet in each bottle and pouch refill.

Learn more about why we chose to add it and how we landed on the peppermint pack.

Is Sleep + Immunity safe to take long-term?

Yes. Proper’s supplements are carefully formulated by Dr. Alice Hirschel, our resident PhD in Nutritional Biochemistry, and reviewed by a world-class panel of medical experts in sleep, integrative, and naturopathic medicine. They are drug-free, non-habit-forming, and safe to take for both short and long-term sleep health.

Sleep + Immunity is for anyone who struggles with poor sleep health (falling asleep, staying asleep, and/or feeling rested upon waking) and is also looking to boost the immune system with a natural solution that fits into their daily wellness routine (it will not "knock you out" or leave you feeling groggy). The primary difference between this supplement and Core Sleep is the addition of Wellmune®—the clinically-studied ingredient with effective immune-boosting properties—along with zinc, vitamin C, vitamin B6, and vitamin D—all of which work to help build a healthy immune response over time.

Results:

In a human clinical study, 250 mg/day of Wellmune® was shown to reduce the number of URTI symptoms supporting a healthy immune response and help strengthen the immune system.

How were the results measured:

A daily health log containing pre-selected questions specific to upper respiratory tract infection (URTI) symptoms—with higher scores indicating more URTI symptoms. Subjects taking Wellmune® reported a 71% decrease in reported URTIs compared to those taking the placebo.

Scientists have concluded that sleep and immunity are “bidirectional,” meaning poor sleep negatively impacts immunity, and an immune response (such as never-ending sniffles or coughing) negatively impacts sleep.

With this in mind, we added Zinc, Vitamins C/D/B6, and Wellmune® to our foundational Core Sleep formulation to create Sleep + Immunity. Subjects taking Wellmune®—a natural beta glucan—reported a 71% decrease in reported upper respiratory tract infections compared to those taking the placebo.

While selecting all ingredients, our PhD-led formulations team followed these core principles:

Ingredients that are 100% traceable to the source
Standardized extracts, tested for quality and potency of active ingredients
Multiple human clinical studies verifying the efficacy of each ingredient AND its dosage—with no conflicting findings. All were double-blind and placebo-controlled.

Once the formulation was developed, we third-party tested it to verify its content and screen for pesticides, heavy metals, and microbes.

Serving Size: 2 Capsules
Servings Per Container: 30

Amount per serving		%DV
Vitamin C (as Ascorbic Acid)	50mg	56%
Zinc (as Zinc Glycinate Chelate)	50mg zinc glycinate chelate (providing 11mg elemental zinc)	100%
Vitamin D (as Cholecalciferol)	25 mcg (1000 IU)	125%
Vitamin B6 (as Pyridoxine Hydrochloride)	1.7 mg	100%
Valerian Root Extract (Valeriana officinalis) (std. to 0.8% Valerenic acid)	300mg	**
Wellmune® (Baker’s Yeast Beta 1,3/1,6 Glucan)	250mg	**
SENSORIL® Ashwagandha Root and Leaf Extract (Withania somnifera) (std. to 10% Withanolides)	125mg	**
GABA (Gamma-Aminobutyric acid)	100mg	**
VENETRON® Rafuma Leaf Extract (Apocynum venetum) (std. to 4% of Hyperoside & isoquercitrin)	50mg	**
**Daily Value (DV) not established

Other Ingredients: Vegetable Cellulose Capsule, Organic Rice Hulls Contains <2% Of: Ascorbyl Palmitate, Calcium Silicate

SENSORIL® is a registered trademark of Natreon, Inc.
Venetron® is a registered trademark of Tokiwa Phytochemical Co., Ltd.
Wellmune® is a registered trademark of Kerry Group.

Select your plan

60 capsules | 30 nights

Sleep + Immunity

Select your plan

60 capsules | 30 nights

Natural + non-habit-forming
Take for at least 5 consecutive nights to start feeling the effects, with full benefits realized after 4 weeks
Contains clinically-studied Wellmune®
Vegan, gluten/allergen/nut/soy/sugar-free, non-GMO, no artificial colors or flavors

When should I take Sleep + Immunity?

Take 2 capsules with water 30-40 minutes before bed.

How long does Sleep + Immunity take to begin working?

How will I feel?

Proper will gently help you relax, fall asleep, and stay asleep. Simply put, it will feel like a good, natural night of sleep.

Do not expect to feel "knocked out," drugged, or groggy. You will awake to normal noises.

79% of Proper customers had less frequent issues staying asleep and 78% were more satisfied with waking up refreshed.*

What's that smell?

Learn more about why we chose to add it and how we landed on the peppermint pack.

Is Sleep + Immunity safe to take long-term?

Results:

In a human clinical study, 250 mg/day of Wellmune® was shown to reduce the number of URTI symptoms supporting a healthy immune response and help strengthen the immune system.

How were the results measured:

While selecting all ingredients, our PhD-led formulations team followed these core principles:

Ingredients that are 100% traceable to the source
Standardized extracts, tested for quality and potency of active ingredients
Multiple human clinical studies verifying the efficacy of each ingredient AND its dosage—with no conflicting findings. All were double-blind and placebo-controlled.

Once the formulation was developed, we third-party tested it to verify its content and screen for pesticides, heavy metals, and microbes.

Serving Size: 2 Capsules
Servings Per Container: 30

Amount per serving		%DV
Vitamin C (as Ascorbic Acid)	50mg	56%
Zinc (as Zinc Glycinate Chelate)	50mg zinc glycinate chelate (providing 11mg elemental zinc)	100%
Vitamin D (as Cholecalciferol)	25 mcg (1000 IU)	125%
Vitamin B6 (as Pyridoxine Hydrochloride)	1.7 mg	100%
Valerian Root Extract (Valeriana officinalis) (std. to 0.8% Valerenic acid)	300mg	**
Wellmune® (Baker’s Yeast Beta 1,3/1,6 Glucan)	250mg	**
SENSORIL® Ashwagandha Root and Leaf Extract (Withania somnifera) (std. to 10% Withanolides)	125mg	**
GABA (Gamma-Aminobutyric acid)	100mg	**
VENETRON® Rafuma Leaf Extract (Apocynum venetum) (std. to 4% of Hyperoside & isoquercitrin)	50mg	**
**Daily Value (DV) not established

Other Ingredients: Vegetable Cellulose Capsule, Organic Rice Hulls Contains <2% Of: Ascorbyl Palmitate, Calcium Silicate

SENSORIL® is a registered trademark of Natreon, Inc.
Venetron® is a registered trademark of Tokiwa Phytochemical Co., Ltd.
Wellmune® is a registered trademark of Kerry Group.

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Ingredients

Ingredient story:

Wellmune® is a natural beta glucan which is highly purified from the cell wall of a proprietary baker’s yeast. Taken daily, Wellmune® has been shown in over 12 human clinical trials to support a healthy immune response. It is absorbed by the lymphatic tissue in the intestine known as Peyer's Patches.

Clinical benefits have been shown to take effect within two weeks. Research shows that Wellmune® also helps reduce the incidence of upper respiratory tract infection symptoms and improve an overall sense of well-being in people of all ages experiencing physical or lifestyle stress.

Highlights:

Supports a healthy immune system + response
Supports the body's immune cell function
Helps strengthen the immune system

Dosing:

Sleep + Immunity contains 250 mg of Wellmune®, a dosage at which clinical benefits have been shown.

Citations:

Carpenter, K. C., W. L. Breslin, T. Davidson, A. Adams, and B. K. Mcfarlin. “Baker's Yeast β-Glucan Supplementation Increases Monocytes and Cytokines Post-Exercise: Implications for Infection Risk?” British Journal of Nutrition 109, no. 3 (2012): 478–86.
Mcfarlin, Brian K., Adam S. Venable, Katie C. Carpenter, Andrea L. Henning, and Stephan Ogenstad. “Oral Supplementation with Baker's Yeast Beta Glucan Is Associated with Altered Monocytes, T Cells and Cytokines Following a Bout of Strenuous Exercise.” Frontiers in Physiology 8 (2017).
Talbott, Shawn M., and Julie A. Talbott. “Baker's Yeast Beta-Glucan Supplement Reduces Upper Respiratory Symptoms and Improves Mood State in Stressed Women.” Journal of the American College of Nutrition 31, no. 4 (2012): 295–300.
Talbott, S. and Talbott, J., 2009. Effect of BETA 1, 3/1, 6 GLUCAN on Upper Respiratory Tract Infection Symptoms and Mood State in Marathon Athletes. Journal of Sports Science and Medicine, 8, pp.509-515.

Ingredient story:

Vitamin C (ascorbic acid) is an essential water-soluble vitamin that must be obtained via diet (good sources include fresh vegetables and fruits, especially citrus fruits) or supplements. This potent antioxidant helps support the body’s natural resistance, in addition to healthy teeth, bones, and skin.

Highlights:

Supports a healthy immune system + response
Protects against free radical damage
Helps support the body’s natural resistance
Supports healthy teeth + bones
Involved in collagen synthesis
Necessary for iron absorption
Supports hormone metabolism
Supports skin health

Dosing:

Sleep + Immunity contains 50mg of vitamin C as ascorbic acid, which represents 56% of the Recommended Dietary Allowance (RDA).

Citations:

Carr, Anitra C, and Silvia Maggini. 2017. “Vitamin C and Immune Function.” Nutrients 9 (11): 1211.

Ingredient story:

Vitamin D (1,25-dihydroxyvitamin D3) is an essential fat-soluble vitamin that must be obtained via sun exposure or diet. It functions as an immune system modulator and steroid hormone that regulates the expression of a variety of target genes. To help protect against infections caused by pathogens, Vitamin D regulates key antimicrobial proteins, stimulates immune cell proliferation, and increases cytokine (proteins that impact cell signaling) production.

Highlights:

Supports a healthy immune system + response
Supports healthy teeth + bones
Facilitates calcium + phosphorus absorption

Dosing:

Sleep + Immunity contains 25 mcg (1000 IU) of vitamin d as cholecalciferol, which represents 125% of the Recommended Dietary Allowance (RDA).

Citations:

Aranow, Cynthia. 2011. “Vitamin D and the Immune System.” Journal of Investigative Medicine : The Official Publication of the American Federation for Clinical Research 59 (6): 881–86.

Ingredient story:

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that must be obtained via diet (good sources include animal protein—e.g., pork, poultry, fish, and eggs—tofu, and avocados) or supplements. Vitamin B6 supports many biochemical reactions in the immune system and is involved in the regulation of immune responses.

Highlights:

Supports healthy immune function
Essential for macronutrient metabolism
Supports nervous system function

Dosing:

Sleep + Immunity contains 1.7 mg of vitamin B6 as pyridoxine hydrochloride, which represents 100% of the Recommended Dietary Allowance (RDA).

Citations:

Yoshii, Ken, Koji Hosomi, Kento Sawane, and Jun Kunisawa. 2019. “Metabolism of Dietary and Microbial Vitamin B Family in the Regulation of Host Immunity.” Frontiers in Nutrition 6 (April).

Ingredient story:

Zinc is an essential mineral that must be obtained via diet (good sources include oysters, red meat, poultry, beans, and nuts) or supplements. The human body requires zinc for the development and functioning of immune cells.

Highlights:

Supports healthy immune function + response
Essential in majority of metabolic processes
Necessary for carbohydrate metabolism
Essential for bone matrix formulation
Involved in collagen synthesis

Dosing:

Sleep + Immunity contains 11 mg of elemental zinc from zinc glycinate chelate, which represents 100% of the Recommended Dietary Allowance (RDA).

Citations:

Prasad, Ananda S. 2008. “Zinc in Human Health: Effect of Zinc on Immune Cells.” Molecular Medicine 14 (5–6): 353–57.
Hojyo, Shintaro, and Toshiyuki Fukada. 2016. “Roles of Zinc Signaling in the Immune System.” Journal of Immunology Research 2016: 1–21.

Ingredient story:

Valeriana officinalis, commonly known as valerian, is an herb native to Europe and Asia whose roots have been used since ancient Greek and Roman times as a sleep promoter. It plays a role prior to and during N1 (first sleep stage), when the body needs to feel calm, relaxed, and drowsy in order to move to N2 (second sleep stage). By working synergistically with a natural amino acid known as GABA, valerian root extract ensures a more relaxed, calm state.

Highlights:

Works synergistically with GABA to ensure a less stimulated response
Together, the two promote a more relaxed, calm mind and body
Promotes restful sleep

Dosing:

Sleep + Immunity contains 300 mg of valerian standardized to a clinically beneficial dosage of 0.8%.

Citations:

Leathwood, Peter D., Françoise Chauffard, Eva Heck, and Raphael Munoz-Box. “Aqueous Extract of Valerian Root (Valeriana Officinalis L.) Improves Sleep Quality in Man.” Pharmacology Biochemistry and Behavior 17, no. 1 (1982): 65–71.
Oxman, Andrew D., Signe Flottorp, Kari Håvelsrud, Atle Fretheim, Jan Odgaard-Jensen, Astrid Austvoll-Dahlgren, Cheryl Carling, Ståle Pallesen, and Bjørn Bjorvatn. “A Televised, Web-Based Randomised Trial of an Herbal Remedy (Valerian) for Insomnia.” PLOS ONE. Public Library of Science. Accessed June 16, 2020.
Santos, Maria, Fernanda Ferreira, António Cunha, Arsélio Carvalho, and Tice Macedo. “An Aqueous Extract of Valerian Influences the Transport of GABA in Synaptosomes.” Planta Medica 60, no. 03 (1994): 278–79.
Morazzoni P, Bombardelli E. “Valeriana officinalis: traditional use and recent evaluation of activity.” Fitoterapia 66: 99-112 (1995)

Learn more:

The Proper Guide To Valerian Root For Sleep: Overview, Uses, Side Effects, + More

Ingredient story:

Ashwagandha is an adaptogen, which refers to a group of herbs that have been used in Ayurveda (traditional Indian medicine) for thousands of years to promote longevity, enhance vitality, support a healthy immune response, enhance focus, and help reduce everyday stress and fatigue.

The Sensoril® Ashwagandha in our supplement is derived from a unique extract of the leaves and roots of the Withania somnifera plant that have been studied in 14 human clinical trials. It has been shown to decrease cortisol (a key marker of stress) and relieve occasional sleeplessness.

Highlights:

Decreases cortisol, a key marker of stress
Reduces malondialdehyde (MDA), a key marker of oxidative stress
Relieves occasional sleeplessness

Dosing:

Sleep + Immunity contains a clinically beneficial dosage + standardization level of 125 mg of Sensoril® Ashwagandha.

Citations:

Auddy B, Hazra J, Mitra A, Abedon B, Ghosal S. “A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans: A double-blind, randomized, placebo-controlled study.” JANA. 2008;11(1): 50-56.

Learn more:

The Proper Guide To Ashwagandha For Stress + Anxiety

Ingredient story:

Gamma-Aminobutyric acid (GABA) is an amino acid produced naturally in the brain. When GABA binds to its receptor (GABA-A), it renders the neuron less responsive to stimulation. In essence, it suppresses or inhibits the central nervous system to reduce excitability and, when bound, produces an immediate calming effect that may support a reduction in stress, anxiety, and sleeplessness.

Highlights:

Reduces excitability
Promotes relaxation + calmness

Dosing:

Sleep + Immunity contains a clinically beneficial dosage of 100 mg of GABA.

Citations:

Abdou, Adham M., S. Higashiguchi, K. Horie, Mujo Kim, H. Hatta, and H. Yokogoshi. “Relaxation and Immunity Enhancement Effects of γ-Aminobutyric Acid (GABA) Administration in Humans.” BioFactors 26, no. 3 (2006): 201–8.
Gottesmann, Claude. “GABA Mechanisms and Sleep.” Neuroscience. Pergamon, April 22, 2002.

Learn more:

The Proper Guide To GABA For Better Sleep

Ingredient story:

Sourced from Japan, Venetron® is a patented, purified, powdered extract from the leaves of a wild perennial plant native to Central Asia and warm regions in Europe: Apocynum venetum L. (or “Rafuma” in Japanese). It has been used for centuries to promote sleep health. By binding to the GABA-A receptor, it reduces excitability and produces a calming effect.

Venetron® has been shown to impact multiple stages of sleep—including N1 and N2, where it has been clinically shown to help sleep initiation, and N3, where it has been shown to enhance non-REM sleep time.

Highlights:

Improves initiation + maintenance of sleep
Helps you fall asleep faster + stay asleep
Reduces feelings of nervousness, restlessness, + irritation

Dosing:

Sleep + Immunity contains a clinically beneficial dosage + standardization level of 50 mg of Venetron®.

Citations:

Yamatsu, Atsushi, Yusuke Yamashita, Isafumi Maru, Jinwei Yang, Jin Tatsuzaki, and Mujo Kim. “The Improvement of Sleep by Oral Intake of GABA and Apocynum Venetum Leaf Extract.” Journal of Nutritional Science and Vitaminology 61, no. 2 (2015): 182–87.
Nakata, A. et al. “Effect of an Apocynum venetum leaf extract (venetron™) on sleep quality and psychological stress improvement.” Japan Pharmacology Therapeutics (JPT), no. 46 (2018): 117-125.

Pair Sleep + Immunity with personalized coaching to optimize your long-term sleep quality

Receive a complimentary coaching session with any formulation subscription!

Proper believes that the most effective solutions are holistic and personalized. That’s why we pair supplements with tailored behavioral sleep support to address the underlying causes of your sleep struggles. Because no one should spend hours sifting through cookie-cutter online sleep tips.

How it works

Complete an intake form to help your coach understand your sleep issues and goals
Schedule a 1:1 Zoom consultation with your expert sleep coach
Get a tailored sleep action plan with sustainable strategies and tips

“I've never felt so ready to wake up early and own the day as I have after taking Proper - I am sleeping uninterrupted from the time I get in bed until it's time to wake up. I am 0% groggy, 100% recharged.”

Gaeb C., New Jersey

Safe

Drug-free, non-habit-forming, & safe to take as part of a long-term sleep wellness routine.

Effective

PhD-designed formulas contain ingredients at dosage levels clinically proven to improve your sleep.

Minimal

Natural, vegan, gluten/dairy/sugar-free, non-GMO. Allergen-free. No artificial colors or binders.

More than Melatonin

It’s great to have options. Melatonin is perfect for some, not for others.

Clean

We third-party test every formula for purity, and verify the absence of heavy metals, microbes, pesticides.

Standard

All of our botanical ingredients are standardized extracts to guarantee consistent purity, potency, and efficacy.

Quality

High quality, natural, and unique ingredients backed by clinical evidence in human trials.

U.S. Manufactured

Produced in a FDA approved facility that is Good Manufacturing Practices and Guidelines (CGMP) compliant.

Thoughtfully delivered natural sleep aids

Small capsules, big impact.
Capsules are designed for efficacy, potency, and minimalism
Smaller capsules lead to greater adherence
No refrigeration needed

Warning

For adults 18 and over only. If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Keep out of reach of children. Do not use it if the seal under the cap is broken or missing. Store at room temperature. Do not consume alcohol, drive or operate machinery after taking this product.

Get better sleep, night after night

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