Prunus cerasus, commonly known as tart cherry, was known to the Greeks as early as 300 B.C. Throughout the centuries since then, this potent ingredient has been used in a variety of foods, including soups, cakes, tarts, and pies. As natural sources of melatonin, tart cherries (and their juice) have been studied as natural sleep remedies shown to increase exogenous melatonin and may lead to improved sleep duration and quality.

• Tart cherries + cherry juice may improve sleep quality
  

Sleep + Restore contains 100 mg of tart cherry, along with 3 mg of melatonin to help support restful and restorative sleep.

• Howatson, Glyn, Phillip G. Bell, Jamie Tallent, Benita Middleton, Malachy P. Mchugh, and Jason Ellis. "Effect of Tart Cherry Juice (Prunus Cerasus) on Melatonin Levels and Enhanced Sleep Quality." European Journal of Nutrition 51, no. 8 (2011): 909-16. doi:10.1007/s00394-011-0263-7.
• St-Onge, Marie-Pierre, Anja Mikic, and Cara E. Pietrolungo. "Effects of Diet on Sleep Quality." Advances in Nutrition 7, no. 5 (2016): 938-49. doi:10.3945/an.116.012336.
• Kelley, Darshan, Yuriko Adkins, and Kevin Laugero. "A Review of the Health Benefits of Cherries." Nutrients 10, no. 3 (2018): 368. doi:10.3390/nu10030368.

• The Proper Guide To Tart Cherry Juice For Sleep: Dosage, Benefits, + More

Valeriana officinalis, commonly known as valerian, is an herb native to Europe and Asia whose roots have been used since ancient Greek and Roman times as a sleep promoter. It plays a role prior to and during N1 (first sleep stage), when the body needs to feel calm, relaxed, and drowsy in order to move to N2 (second sleep stage). By working synergistically with a natural amino acid known as GABA, valerian root extract ensures a more relaxed, calm state.

• Works synergistically with GABA to ensure a less stimulated response
• Together, the two promote a more relaxed, calm mind and body
• Promotes restful sleep

Sleep + Restore contains 300 mg of valerian standardized to a clinically beneficial dosage of 0.8%.

• Leathwood, Peter D., Françoise Chauffard, Eva Heck, and Raphael Munoz-Box. “Aqueous Extract of Valerian Root (Valeriana Officinalis L.) Improves Sleep Quality in Man.” Pharmacology Biochemistry and Behavior 17, no. 1 (1982): 65–71.
• Oxman, Andrew D., Signe Flottorp, Kari Håvelsrud, Atle Fretheim, Jan Odgaard-Jensen, Astrid Austvoll-Dahlgren, Cheryl Carling, Ståle Pallesen, and Bjørn Bjorvatn. “A Televised, Web-Based Randomised Trial of an Herbal Remedy (Valerian) for Insomnia.” PLOS ONE. Public Library of Science. Accessed June 16, 2020.
• Santos, Maria, Fernanda Ferreira, António Cunha, Arsélio Carvalho, and Tice Macedo. “An Aqueous Extract of Valerian Influences the Transport of GABA in Synaptosomes.” Planta Medica 60, no. 03 (1994): 278–79.
• Morazzoni P, Bombardelli E. “Valeriana officinalis: traditional use and recent evaluation of activity.” Fitoterapia 66: 99-112 (1995)

• The Proper Guide To Valerian Root For Sleep: Overview, Uses, Side Effects, + More

Ashwagandha is an adaptogen, which refers to a group of herbs that have been used in Ayurveda (traditional Indian medicine) for thousands of years to promote longevity, enhance vitality, support a healthy immune response, enhance focus, and help reduce everyday stress and fatigue.

The Sensoril® Ashwagandha in our supplement is derived from a unique extract of the leaves and roots of the Withania somnifera plant that have been studied in 14 human clinical trials. It has been shown to decrease cortisol (a key marker of stress) and relieve occasional sleeplessness.

• Decreases cortisol, a key marker of stress
• Reduces malondialdehyde (MDA), a key marker of oxidative stress
• Relieves occasional sleeplessness

Sleep + Restore contains a clinically beneficial dosage + standardization level of 125 mg of Sensoril® Ashwagandha.

• Auddy B, Hazra J, Mitra A, Abedon B, Ghosal S. “A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans: A double-blind, randomized, placebo-controlled study.” JANA. 2008;11(1): 50-56.

• The Proper Guide To Ashwagandha For Stress + Anxiety

Gamma-Aminobutyric acid (GABA) is an amino acid produced naturally in the brain. When GABA binds to its receptor (GABA-A), it renders the neuron less responsive to stimulation. In essence, it suppresses or inhibits the central nervous system to reduce excitability and, when bound, produces an immediate calming effect that may support a reduction in stress, anxiety, and sleeplessness.

• Reduces excitability
• Promotes relaxation + calmness

Sleep + Restore contains a clinically beneficial dosage of 100 mg of GABA.

• Abdou, Adham M., S. Higashiguchi, K. Horie, Mujo Kim, H. Hatta, and H. Yokogoshi. “Relaxation and Immunity Enhancement Effects of γ-Aminobutyric Acid (GABA) Administration in Humans.” BioFactors 26, no. 3 (2006): 201–8.
• Gottesmann, Claude. “GABA Mechanisms and Sleep.” Neuroscience. Pergamon, April 22, 2002.

• The Proper Guide To GABA For Better Sleep

Sourced from Japan, Venetron® is a patented, purified, powdered extract from the leaves of a wild perennial plant native to Central Asia and warm regions in Europe: Apocynum venetum L. (or “Rafuma” in Japanese). It has been used for centuries to promote sleep health. By binding to the GABA-A receptor, it reduces excitability and produces a calming effect.

Venetron® has been shown to impact multiple stages of sleep—including N1 and N2, where it has been clinically shown to help sleep initiation, and N3, where it has been shown to enhance non-REM sleep time.

• Improves initiation + maintenance of sleep
• Helps you fall asleep faster + stay asleep
• Reduces feelings of nervousness, restlessness, + irritation

Sleep + Restore contains a clinically beneficial dosage + standardization level of 50 mg of Venetron®.

• Yamatsu, Atsushi, Yusuke Yamashita, Isafumi Maru, Jinwei Yang, Jin Tatsuzaki, and Mujo Kim. “The Improvement of Sleep by Oral Intake of GABA and Apocynum Venetum Leaf Extract.” Journal of Nutritional Science and Vitaminology 61, no. 2 (2015): 182–87.
• Nakata, A. et al. “Effect of an Apocynum venetum leaf extract (venetron™) on sleep quality and psychological stress improvement.” Japan Pharmacology Therapeutics (JPT), no. 46 (2018): 117-125.

• Refillable glass jar
• Recyclable cardboard packaging
• Subscribers receive refill pouches that are recyclable